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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls

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In recent years, various approaches have been developed to promote induction of MSCs into Schwann-like cells, particularly the use of certain small molecules or growth factors [48, 50] and engineered substrates or scaffolds such as graphene oxide substrate [51], 3D-printed polycaprolactone/polypyrrole (PCL/PPy) conductive scaffold [52], 3D-printed bionic polycaprolactone (PCL) polymer scaffold [53], and aligned nanofibers [54]